IUSM-Purdue Cores

Links to each core:

Admin and Data Management

Location: Indiana University School of Medicine

Goals:

• Provide effective management, oversight, and evaluation of the IUSM-Purdue’s highly integrated Core activities along with communication to key stakeholders including the CSC, EAB, and the AD Research community.
• Ensure timely and successful completion of center aims and delivery on key milestones and associated criteria.
• Create and manage a dynamic open sharing data platform that will facilitate broad community access to all Center experimental activity, along with key tools and methods as part of specific TEPs.

Staff:

Bioinformatics and Computational Biology (BCB)

Location: Indiana University School of Medicine, Regenstrief Institute

Goals:

• Lead the development of the Open Access Data Sharing (OADS) platform.
• Develop and establish advanced and novel data integration methods for predicting and prioritizing druggable targets as well as potential repurposing of drug candidates for AD.
• Provide bioinformatics data processing and analysis support for the entire project covering the lifecycle of Alzheimer’s Disease drug target identification and drug discovery, by closely collaborating and coordinating with other technical cores.

Staff:

Structural Biology and Biophysics (SBB)

Location: Purdue University

Goal:

• Enable the identification of hit molecules by first elucidating unknown structures for prioritized targets via x-ray diffraction or cryo-electron microscopy, then utilizing those structures (or already known published structures) to perform computer aided drug design via multiple in silico methods in partnership with the Medicinal Chemistry and Chemical Biology (MCCB) Core.

Staff:

Assay Development and High-Throughput Screening (AD-HTS)

Location: Purdue University

Goals:

• Perform primary and secondary assay enablement studies on selected targets to support compound screening and iterative SAR studies
• For targets that are advanced for lead discovery, the AD-HTS Core contributes to the design of a specific lead generation strategy and enables the in vitro testing flow scheme.

Staff:

Medicinal Chemistry and Chemical Biology (MCCB)

Locations: Indiana University School of Medicine, Purdue University, and University of Pittsburgh

Goals: 

• Consultation on target selection including assessment of druggability and aid in enablement studies
• Design the lead generation strategy for each prioritized target
• Work with cross-functional scientists from Technical Cores to enable hit discovery and iterative hit-to-lead SAR studies
• Aid in vitro and in vivo assay/model study design and assessment of compound performance
• Conduct multiparameter problem solving to optimize compound performance
• Provide technical review and recommendation on lead milestone for prioritized projects, and
• Provide termination recommendation for projects that have low likelihood for technical success

Staff: