Emory-Sage-SGC Cores

Links to each core:

Admin and Data
Bioinformatics
Structural Biology
Assay Development and High-Throughput Screening
Medicinal Chemistry

Admin and Data Management

Locations: Emory University, Sage Bionetworks, University of Toronto, Stanford University, Structural Genomics Consortium

Goals:

  • Provide oversight and administrative support across the Center.
  • Manage the selection of a diverse portfolio of targets.
  • Support communication between Emory-Sage-SGC and external researchers to guide Center activities, inform Center decisions, and promote Center assets for external use.
  • Openly distribute all data, methods, reagents, probes, and decision-making. content from within the Center to the broader research community.

Staff:

Name Role Affiliation
Allan Levey MPI, Admin, ADHC Lead Emory University
Frank Longo MPI, Admin Stanford University
Aled Edwards MPI, Admin SGC and University of Toronto
Paul Brennan MPI, Admin, Struc Bio Core Lead University of Oxford
Haian Fu MPI, Admin, ADHC Core Lead Emory University
Alison Axtman MPI, Admin, Medicinal Chemistry Core Lead SGC and University of North Carolina
Anna Greenwood MPI, Admin, Data Core Lead Sage Bionetworks
Ranjita Betarbet Research Administrator, Co-I ADHC Emory University
Karina Leal Center Director of Operations Sage Bionetworks

Bioinformatics

Locations: Sage Bionetworks and The Jackson Laboratory

Goals:

  • Evaluate the available evidence for nominated targets
  • Identify suitable AD relevant mechanisms for targets
  • Prioritize targets and target hypotheses

Staff:

Name Role Affiliation
Gregory Carter MPI, Bioinformatics Core Lead The Jackson Laboratory
Allan Levey MPI, Admin/Data, ADHC Lead Emory University
Nicholas Seyfried Bioinformatics Core Emory University
Erik Johnson Bioinformatics Core Emory University
Thomas Wingo Bioinformatics Core Emory University
Anna Greenwood Data Core Lead Sage Bionetworks
Karina Leal Center Director of Operations Sage Bionetworks
Jesse Wiley Bioinformatics Core Sage Bionetworks
Greg Cary Bioinformatics Core The Jackson Laboratory
Stephen Keegan Bioinformatics Core The Jackson Laboratory
Frank Longo MPI, Admin/Data Stanford University
Robert Butler Bioinformatics Core Stanford University
Joshua Shulman Bioinformatics Core, Co-I ADHC Core Baylor College of Medicine
Suman Jayadev Bioinformatics Core, Co-I ADHC Core University of Washington
Jessica Young Bioinformatics Core, Co-I ADHC Core University of Washington
Lea Grinberg Bioinformatics Core University of California, San Francisco

Structural Biology

Locations: University of Oxford and Structural Genomics Consortium

Goal:

  • Deliver Target Enabling Packages (TEPs) for new targets prioritized by Emory-Sage-SGC. The TEPs include tools for investigating target biology, for evaluating druggability, and for initiating medicinal chemistry programs.

Staff:

Name Role Affiliation
Paul Brennan MPI, Structural Biology Core Lead University of Oxford and SGC
Vito Katis Structural Biology Core University of Oxford and SGC
Karolina Rygiel Project Coord & Target Analyst, Struc Bio Core University of Oxford and SGC
William Bradshaw Structural Biology Core University of Oxford and SGC
Katerina Gospodinova Structural Biology Core University of Oxford and SGC

Assay Development and High-Throughput Screening

Location: Emory University

Goals:

  • Target characterization
  • High-throughput screening
  • Hit validation
  • Chemical probe optimization

Staff:

Name Role Affiliation
Haian Fu MPI, Admin/Data, ADHC Core Lead Emory University
Allan Levey MPI, Admin/Data, ADHC Lead Emory University
Yuhong Du Co-Investigator, ADHC Emory University
Andrey Ivanov Co-Investigator, ADHC Emory University
Min Qui Lead research specialist (HTS), ADHC Emory University
Ranjita Betarbet Co-I, ADHC, Research Administrator, Admin/Data Emory University
Aled Edwards MPI, Admin/Data SGC and University of Toronto
Suman Jayadev Co-Investigator, ADHC University of Washington
Jessica Young Co-Investigator, ADHC University of Washington
Stacey Rizzo Co-Investigator, ADHC University of Pittsburgh
Suzanne Doolen Project Manager, ADHC University of Pittsburgh
Juan Botas Co-Investigator, ADHC Baylor College of Medicine
Joshua Shulman Co-Investigator, ADHC Core Baylor College of Medicine
Zhandong Liu Co-Investigator, ADHC Baylor College of Medicine
Tom Lee Instructor, ADHC Baylor College of Medicine
David Li-Kroeger Postdoctoral Research Fellow, ADHC Baylor College of Medicine

Medicinal Chemistry

Location: University of North Carolina at Chapel Hill

Goal: Deliver 3 cellular and 1-2 in vivo probes per year versus novel targets implicated in AD, which will be made freely available to the scientific community.

Staff:

Name Role Affiliation
Alison Axtman MPI, Admin/Data, Med Chem Core Lead University of North Carolina at Chapel Hill
Jeff Aubé Co-Investigator, Medicinal Chemistry University of North Carolina at Chapel Hill
Kevin Frankowski Co-Investigator, Medicinal Chemistry University of North Carolina at Chapel Hill
Brian Hardy Compound and Laboratory Manager, Lead Discovery and Characterization University of North Carolina at Chapel Hill
Dimitri Kireev Co-Investigator, Computational Chemistry University of North Carolina at Chapel Hill
Ken Pearce Co-Investigator, Lead Discovery, Characterization and Project Manager University of North Carolina at Chapel Hill
Michael Stashko Research Associate, Lead Discovery and Characterization University of North Carolina at Chapel Hill
Xiaodong Wang Co-Investigator, Medicinal Chemistry University of North Carolina at Chapel Hill
Tim Willson Co-Investigator, Medicinal Chemistry University of North Carolina at Chapel Hill and SGC
Karem Ahmed El Mansour Galal Postdoctoral Research Fellow, Medicinal Chemistry University of North Carolina at Chapel Hill
Frances Mead Potjewyd Postdoctoral Research Fellow, Medicinal Chemistry University of North Carolina at Chapel Hill
Tina Leisner Research Associate, Medicinal Chemistry University of North Carolina at Chapel Hill
Xiaowen Wang Postdoctoral Fellow, Medicinal Chemistry University of North Carolina at Chapel Hill
Dilipkumar Uredi Postdoctoral Fellow, Medicinal Chemistry University of North Carolina at Chapel Hill
Arumina Sikdar Postdoctoral Research Fellow, Medicinal Chemistry University of North Carolina at Chapel Hill