Emory-Sage-SGC Cores

Links to each core:

Admin and Data Management

Locations: Emory University, Sage Bionetworks, University of Toronto, Stanford University, Structural Genomics Consortium

Goals:

  • Provide oversight and administrative support across the Center.
  • Manage the selection of a diverse portfolio of targets.
  • Support communication between Emory-Sage-SGC and external researchers to guide Center activities, inform Center decisions, and promote Center assets for external use.
  • Openly distribute all data, methods, reagents, probes, and decision-making. content from within the Center to the broader research community.

Staff:

Name Role Affiliation
Allan Levey MPI, Admin/Data, ADHC Lead Emory University
Lara Mangravite MPI, Admin/Data Sage Bionetworks
Frank Longo MPI, Admin/Data Stanford University
Aled Edwards MPI, Admin/Data SGC and University of Toronto
Opher Gileadi MPI, Admin/Data, Struc Bio Core Lead SGC and University of Oxford
Haian Fu MPI, Admin/Data, ADHC Core Lead Emory University
Stephen Frye MPI, Admin/Data, Med Chem Core Lead University of North Carolina at Chapel Hill
Larsson Omberg Data Core Lead Sage Bionetworks
Anna Greenwood Project Manager Sage Bionetworks
Erin Scanlan Executive Assistant Sage Bionetworks
Ranjita Betarbet Research Administrator, Co-I ADHC Emory University
Karina Leal PM, Admin/Data Sage Bionetworks

Bioinformatics

Locations: Sage Bionetworks and The Jackson Laboratory

Goals:

  • Evaluate the available evidence for nominated targets
  • Identify suitable AD relevant mechanisms for targets
  • Prioritize targets and target hypotheses

Staff:

Name Role Affiliation
Gregory Carter Bioinformatics Core Lead The Jackson Laboratory
Allan Levey MPI, Admin/Data, ADHC Lead Emory University
Nicholas Seyfried Bioinformatics Core Emory University
Erik Johnson Bioinformatics Core Emory University
Thomas Wingo Bioinformatics Core Emory University
Lara Mangravite MPI, Admin/Data Sage Bionetworks
Larsson Omberg Data Core Lead Sage Bionetworks
Anna Greenwood Project Manager Sage Bionetworks
Karina Leal Project Manager, Admin/Data Sage Bionetworks
Jake Gockley Bioinformatics Core Sage Bionetworks
Jesse Wiley Bioinformatics Core Sage Bionetworks
Greg Cary Bioinformatics Core The Jackson Laboratory
Frank Longo MPI, Admin/Data Stanford University
Robert Butler Bioinformatics Core Stanford University
Joshua Shulman Bioinformatics Core, Co-I ADHC Core Baylor College of Medicine
Suman Jayadev Bioinformatics Core, Co-I ADHC Core University of Washington
Jessica Young Bioinformatics Core, Co-I ADHC Core University of Washington
Lea Grinberg Bioinformatics Core University of California, San Francisco

Structural Biology

Locations: University of Oxford and Structural Genomics Consortium

Goal:

  • Deliver Target Enabling Packages (TEPs) for new targets prioritized by Emory-Sage-SGC. The TEPs include tools for investigating target biology, for evaluating druggability, and for initiating medicinal chemistry programs.

Staff:

Name Role Affiliation
Opher Gileadi MPI, Admin/Data, Structural Biology Core Lead University of Oxford and SGC
Vito Katis Structural Biology Core University of Oxford and SGC
Karolina Rygiel Project Coord & Target Analyst, Struc Bio Core University of Oxford and SGC
William Bradshaw Structural Biology Core University of Oxford and SGC
Elena Di Daniel Structural Biology Core ARUK Oxford Drug Discovery Institute,
University of Oxford

Assay Development and High-Throughput Screening

Location: Emory University

Goals:

  • Target characterization
  • High-throughput screening
  • Hit validation
  • Chemical probe optimization

Staff:

Name Role Affiliation
Haian Fu MPI, Admin/Data, ADHC Core Lead Emory University
Allan Levey MPI, Admin/Data, ADHC Lead Emory University
Rachel Commander Project Manager, ADHC Emory University
Yuhong Du Co-Investigator, ADHC Emory University
Andrey Ivanov Co-Investigator, ADHC Emory University
Kun Qian Postdoctoral Research Fellow, ADHC Emory University
Min Qui Lead research specialist (HTS), ADHC Emory University
Ranjita Betarbet Co-I, ADHC, Research Administrator, Admin/Data Emory University
Aled Edwards MPI, Admin/Data SGC and University of Toronto
Suman Jayadev Co-Investigator, ADHC University of Washington
Jessica Young Co-Investigator, ADHC University of Washington
Stacey Rizzo Co-Investigator, ADHC University of Pittsburgh
Suzanne Doolen Project Manager, ADHC University of Pittsburgh
Juan Botas Co-Investigator, ADHC Baylor College of Medicine
Joshua Shulman Co-Investigator, ADHC Core Baylor College of Medicine
Zhandong Liu Co-Investigator, ADHC Baylor College of Medicine
Tom Lee Instructor, ADHC Baylor College of Medicine
David Li-Kroeger Postdoctoral Research Fellow, ADHC Baylor College of Medicine

Medicinal Chemistry

Location: University of North Carolina at Chapel Hill

Goal: Deliver 3 cellular and 1-2 in vivo probes per year versus novel targets implicated in AD, which will be made freely available to the scientific community.

Staff:

Name Role Affiliation
Stephen Frye MPI, Admin/Data, Med Chem Core Lead University of North Carolina at Chapel Hill
Jeff Aubé Co-Investigator, Medicinal Chemistry University of North Carolina at Chapel Hill
Alison Axtman Co-Investigator, Medicinal Chemistry University of North Carolina at Chapel Hill and SGC
Kevin Frankowski Co-Investigator, Medicinal Chemistry University of North Carolina at Chapel Hill
Brian Hardy Compound and Laboratory Manager, Lead Discovery and Characterization University of North Carolina at Chapel Hill
Dimitri Kireev Co-Investigator, Computational Chemistry University of North Carolina at Chapel Hill
Ken Pearce Co-Investigator, Lead Discovery, Characterization and Project Manager University of North Carolina at Chapel Hill
Michael Stashko Research Associate, Lead Discovery and Characterization University of North Carolina at Chapel Hill
Xiaodong Wang Co-Investigator, Medicinal Chemistry University of North Carolina at Chapel Hill
Carrow Wells Co-Investigator, Medicinal Chemistry University of North Carolina at Chapel Hill and SGC
Tim Willson Co-Investigator, Medicinal Chemistry University of North Carolina at Chapel Hill and SGC
Felix Nwogbo Postdoctoral Research Fellow, Medicinal Chemistry University of North Carolina at Chapel Hill
Frances Mead Potjewyd Postdoctoral Research Fellow, Medicinal Chemistry University of North Carolina at Chapel Hill
Joel Annor-Gyamfi Postdoctoral Research Fellow, Medicinal Chemistry University of North Carolina at Chapel Hill
Shiva Guduru Postdoctoral Research Fellow, Medicinal Chemistry University of North Carolina at Chapel Hill