Emory-Sage-SGC-JAX Cores
Links to each core:
Admin and Data Management
Locations: Emory University, Sage Bionetworks, Structural Genomics Consortium, Jackson Laboratory
Goals:
- Provide oversight and administrative support across the Center.
- Manage the selection of a diverse portfolio of targets.
- Support communication between Emory-Sage-SGC-JAX and external researchers to guide Center activities, inform Center decisions, and promote Center assets for external use.
- Openly distribute all data, methods, reagents, and probes from within the Center to the broader research community.
Staff:
| Name | Role | Affiliation |
|---|---|---|
| Allan Levey | MPI, Admin, ADHC Lead | Emory University |
| Frank Longo | MPI, Admin | Stanford University |
| Aled Edwards | MPI, Admin, Structural Biology Core Lead | SGC-University of Toronto |
| Haian Fu | MPI, Admin, ADHC Core Lead | Emory University |
| Alison Axtman | MPI, Admin, Medicinal Chemistry Core Lead | SGC-University of North Carolina |
| Anna Greenwood | MPI, Admin, Data Core Lead | Sage Bionetworks |
| Ranjita Betarbet | Research Administrator, Co-I ADHC | Emory University |
| Karina Leal | Center Director of Operations | Sage Bionetworks |
Bioinformatics
Locations: The Jackson Laboratory, Sage Bionetworks, Stanford University, UC San Francisco
Goals:
- Evaluate the available evidence for nominated targets
- Identify suitable AD relevant mechanisms for targets
- Prioritize targets and target hypotheses
Staff:
| Name | Role | Affiliation |
|---|---|---|
| Gregory Carter | MPI, Bioinformatics Core Lead | The Jackson Laboratory |
| Greg Cary | Bioinformatics Core | The Jackson Laboratory |
| Jesse Wiley | Bioinformatics Core | Sage Bionetworks |
| Frank Longo | MPI, Admin/Data | Stanford University |
| Robert Butler | Bioinformatics Core | Stanford University |
| Lea Grinberg | Bioinformatics Core | University of California, San Francisco |
Structural Biology
Location: Structural Genomics Consortium – University of Toronto
Goal:
- The goal of the Structural Biology Core is to lead the development of experimental target enabling packages (TEPs) for AD targets, providing the crucial starting points for testing new therapeutic hypotheses in AD.
Staff:
| Name | Role | Affiliation |
|---|---|---|
| Aled Edwards | MPI, Structural Biology Core Lead | University of Toronto-SGC |
| Levon Halabelian | PI, Structural Biology Core | University of Toronto-SGC |
| Carl Laflamme | Structural Biology Core | YCharOS |
Assay Development and High-Throughput Screening
Location: Emory University
Goals:
- The Assay Core will design, develop, and implement innovative and informative assays to facilitate target nomination with the Bioinformatics Core, TEP development with Structural Biology Core and Medicinal Chemistry, and evaluate biological and chemical probes developed by the center.
Staff:
| Name | Role | Affiliation |
|---|---|---|
| Haian Fu | MPI, Admin/Data, ADHC Core Lead | Emory University |
| Allan Levey | MPI, Admin/Data, ADHC Lead | Emory University |
| Yuhong Du | Co-Investigator, ADHC | Emory University |
| Andrey Ivanov | Co-Investigator, ADHC | Emory University |
| Ranjita Betarbet | Co-I, ADHC, Research Administrator, Admin/Data | Emory University |
| Elizabeth Zoeller | Project Coordinator | Emory University |
| Suman Jayadev | Co-Investigator, ADHC | University of Washington |
| Jessica Young | Co-Investigator, ADHC | University of Washington |
| Stacey Rizzo | Co-Investigator, ADHC | University of Pittsburgh |
Medicinal Chemistry
Location: SGC-University of North Carolina at Chapel Hill
Goal:The MedChem Core will contribute to the development of experimental TEPs for AD targets by identifying, characterizing, and/or optimizing small molecule tools.
Staff:
| Name | Role | Affiliation |
|---|---|---|
| Alison Axtman | MPI, Admin/Data, Med Chem Core Lead | University of North Carolina at Chapel Hill |
| Kevin Frankowski | Co-Investigator, Medicinal Chemistry | University of North Carolina at Chapel Hill |
| Brian Hardy | Compound and Laboratory Manager, Lead Discovery and Characterization | University of North Carolina at Chapel Hill |
| Ken Pearce | Co-Investigator, Lead Discovery, Characterization and Project Manager | University of North Carolina at Chapel Hill |
| Michael Stashko | Research Associate, Lead Discovery and Characterization | University of North Carolina at Chapel Hill |
| Xiaodong Wang | Co-Investigator, Medicinal Chemistry | University of North Carolina at Chapel Hill |
| Tim Willson | Co-Investigator, Medicinal Chemistry | University of North Carolina at Chapel Hill and SGC |
| Frances Mead Potjewyd | Postdoctoral Research Fellow, Medicinal Chemistry | University of North Carolina at Chapel Hill |
| Tina Leisner | Research Associate, Medicinal Chemistry | University of North Carolina at Chapel Hill |
| Arumina Sikdar | Postdoctoral Research Fellow, Medicinal Chemistry | University of North Carolina at Chapel Hill |